The 2017-2018 seasonal influenza epidemics are severe in the US and Australia where A (H3N2) virus subtype dominated. Although circulating A (H3N2) virus antigen is not different from that recommended by the WHO for vaccine production, the overall interim estimate of vaccine effectiveness was under the historical average (33%) for A (H3N2) virus. The majority (USA) or all (Australia) dose of vaccine contains several amino acid changes in the hemagglutinin protein, which is produced from the necessary adaptation of the virus to embryonated chicken eggs used to manufacture the vaccine most. Previous reports have suggested the potential negative impact of the substitution of egg-driven performance of the vaccine. With the support of Barda, two vaccines licensed in the US is produced in cell culture: a recombinant influenza vaccine (RIV, Flublok ™) produced in insect cells and inactivated vaccines adult mammalian cells (ccIIV, Flucelvax ™). CcIIV quadrivalent (ccIIV4) vaccine for the 2017-2018 influenza season was produced using seed virus A (H3N2) distributed exclusively in cell culture and therefore less adaptative changes eggs. ccIIV dose fairly distributed (but not RIV dose) to allow the initial estimates of higher efficacy relative to traditional egg-based vaccine, the study details pending. The increased availability of certain product comparison vaccine effectiveness estimates for cell-based vaccine and egg-based can provide important clues to inform vaccine product improvements moving forward.
Diclofenac Diethylamine |
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| B1928-50 | ApexBio | 50 mg | EUR 128 |
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Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Diclofenac Diethylamine |
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| B1928-S | ApexBio | Evaluation Sample | EUR 81 |
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Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
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Sarafloxacin Hydrochloride |
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| S003-25G | TOKU-E | 25 g | EUR 168 |
Sarafloxacin Hydrochloride |
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| S003-5G | TOKU-E | 5 g | EUR 74 |
Sancycline hydrochloride |
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| S076-10MG | TOKU-E | 10 mg | EUR 128 |
Sancycline hydrochloride |
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| S076-50MG | TOKU-E | 50 mg | EUR 440 |
Moxifloxacin Hydrochloride |
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| M033-100MG | TOKU-E | 100 mg | EUR 129 |
Moxifloxacin Hydrochloride |
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| M033-500MG | TOKU-E | 500 mg | EUR 424 |
Metformin hydrochloride |
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| M087-1G | TOKU-E | 1 g | EUR 47 |
Metformin hydrochloride |
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| M087-5G | TOKU-E | 5 g | EUR 52 |
Naftifine hydrochloride |
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| N047-500MG | TOKU-E | 500 mg | EUR 709 |
Naftifine hydrochloride |
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| N047-50MG | TOKU-E | 50 mg | EUR 138 |
Oxytetracycline Hydrochloride |
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| O004-100G | TOKU-E | 100 g | EUR 171 |
Oxytetracycline Hydrochloride |
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| O004-10G | TOKU-E | 10 g | EUR 66 |
Oxytetracycline Hydrochloride |
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| O004-50G | TOKU-E | 50 g | EUR 114 |
Ofloxacin Hydrochloride |
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| O039-10G | TOKU-E | 10g | EUR 163 |
Lomefloxacin hydrochloride |
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| L005-1G | TOKU-E | 1 g | EUR 74 |
Lomefloxacin hydrochloride |
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| L005-5G | TOKU-E | 5 g | EUR 153 |
Methacycline hydrochloride |
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| M003-100MG | TOKU-E | 100 mg | EUR 139 |
Methacycline hydrochloride |
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| M003-1G | TOKU-E | 1 g | EUR 187 |
Minocycline hydrochloride |
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| M008-1G | TOKU-E | 1 g | EUR 347 |
Minocycline hydrochloride |
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| M008-500MG | TOKU-E | 500 mg | EUR 200 |
Mitoxantrone hydrochloride |
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| M010-50MG | TOKU-E | 50 mg | EUR 129 |
Pirlimycin Hydrochloride |
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| P088-25MG | TOKU-E | 25 mg | EUR 670 |
Pirlimycin Hydrochloride |
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| P088-5MG | TOKU-E | 5 mg | EUR 213 |
Ofloxacin Hydrochloride |
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| O039-1G | TOKU-E | 1g | EUR 63 |
Tasidotin hydrochloride |
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| HY-13760 | MedChemExpress | 5mg | EUR 2198 |
Topotecan (Hydrochloride) |
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| HY-13768A | MedChemExpress | 10mg | EUR 119 |
Hydroxyfasudil (hydrochloride) |
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| HY-13911A | MedChemExpress | 10mM/1mL | EUR 168 |
Sevelamer hydrochloride |
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| HY-13995A | MedChemExpress | 100mg | EUR 153 |
Rimonabant (Hydrochloride) |
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| HY-14137 | MedChemExpress | 100mg | EUR 463 |
Cinaciguat (hydrochloride) |
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| HY-14181A | MedChemExpress | 50mg | EUR 1290 |
Vernakalant (Hydrochloride) |
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| HY-14183 | MedChemExpress | 5mg | EUR 366 |
Amiodarone (hydrochloride) |
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| HY-14188 | MedChemExpress | 500mg | EUR 108 |
Clorgyline hydrochloride |
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| HY-14197A | MedChemExpress | 100mg | EUR 380 |
Siramesine (hydrochloride) |
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| HY-14221A | MedChemExpress | 50mg | EUR 1290 |
Fadrozole hydrochloride |
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| HY-14247 | MedChemExpress | 100mg | EUR 614 |
Olprinone (Hydrochloride) |
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| HY-14254 | MedChemExpress | 50mg | EUR 452 |
Vilazodone (Hydrochloride) |
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| HY-14261 | MedChemExpress | 10mg | EUR 119 |
Tebanicline (hydrochloride) |
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| HY-14316A | MedChemExpress | 100mg | EUR 1069 |
Idalopirdine Hydrochloride |
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| HY-14338A | MedChemExpress | 50mg | EUR 1297 |
Haloperidol (hydrochloride) |
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| HY-14538A | MedChemExpress | 500mg | EUR 160 |
Ziprasidone (hydrochloride) |
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| HY-14542A | MedChemExpress | 50mg | EUR 277 |
Amisulpride (hydrochloride) |
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| HY-14545A | MedChemExpress | 100mg | EUR 160 |
Talnetant (hydrochloride) |
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| HY-14552A | MedChemExpress | 10mg | EUR 236 |
Idazoxan (hydrochloride) |
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| HY-14561A | MedChemExpress | 50mg | EUR 136 |
Pioglitazone (hydrochloride) |
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| HY-14601 | MedChemExpress | 100mg | EUR 119 |
MPEP (Hydrochloride) |
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| HY-14609 | MedChemExpress | 50mg | EUR 366 |
Diltiazem (hydrochloride) |
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| HY-14656 | MedChemExpress | 1g | EUR 119 |
CCT241533 (hydrochloride) |
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| HY-14715B | MedChemExpress | 100mg | EUR 1745 |
Resminostat (hydrochloride) |
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| HY-14718A | MedChemExpress | 10mM/1mL | EUR 307 |
Anamorelin (hydrochloride) |
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| HY-14734A | MedChemExpress | 5mg | EUR 147 |
Golotimod (hydrochloride) |
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| HY-14743B | MedChemExpress | 5mg | EUR 452 |
Cariprazine (hydrochloride) |
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| HY-14763A | MedChemExpress | 5mg | EUR 215 |
Imeglimin (hydrochloride) |
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| HY-14771A | MedChemExpress | 10mM/1mL | EUR 429 |
Befiradol (hydrochloride) |
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| HY-14785A | MedChemExpress | 10mM/1mL | EUR 744 |
Givinostat (hydrochloride) |
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| HY-14842A | MedChemExpress | 100mg | EUR 1703 |
Lasmiditan (hydrochloride) |
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| HY-14861A | MedChemExpress | 100mg | EUR 796 |
Omadacycline (hydrochloride) |
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| HY-14865C | MedChemExpress | 50mg | EUR 2116 |
Fabomotizole (hydrochloride) |
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| HY-14895A | MedChemExpress | 100mg | EUR 1714 |
Arbidol (hydrochloride) |
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| HY-14904A | MedChemExpress | 50mg | EUR 298 |
Migalastat (hydrochloride) |
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| HY-14929A | MedChemExpress | 25mg | EUR 587 |
Pardoprunox (hydrochloride) |
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| HY-14958A | MedChemExpress | 100mg | EUR 2943 |
R1487 (Hydrochloride) |
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| HY-14975 | MedChemExpress | 100mg | EUR 1139 |
Sinomenine hydrochloride |
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| HY-15122A | MedChemExpress | 100mg | EUR 119 |
Doxorubicin (hydrochloride) |
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| HY-15142 | MedChemExpress | 100mg | EUR 147 |
SBE13 (Hydrochloride) |
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| HY-15158 | MedChemExpress | 10mg | EUR 162 |
Icotinib (Hydrochloride) |
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| HY-15164 | MedChemExpress | 10mM/1mL | EUR 138 |
Pyridostatin (hydrochloride) |
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| HY-15176A | MedChemExpress | 10mg | EUR 195 |
Buparlisib (Hydrochloride) |
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| HY-15180 | MedChemExpress | 10mg | EUR 173 |
Agerafenib hydrochloride |
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| HY-15199 | MedChemExpress | 100mg | EUR 1703 |
EPZ004777 (hydrochloride) |
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| HY-15227A | MedChemExpress | 10mg | EUR 312 |
XL413 (hydrochloride) |
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| HY-15260A | MedChemExpress | 5mg | EUR 215 |
Prasugrel (hydrochloride) |
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| HY-15284A | MedChemExpress | 100mg | EUR 326 |
S107 hydrochloride |
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| HY-15292A | MedChemExpress | 50mg | EUR 670 |
CBB1007 (hydrochloride) |
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| HY-15313B | MedChemExpress | 100mg | EUR 1882 |
PRT062607 (Hydrochloride) |
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| HY-15323 | MedChemExpress | 10mM/1mL | EUR 229 |
Atrasentan (hydrochloride) |
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| HY-15403A | MedChemExpress | 10mM/1mL | EUR 349 |
Encenicline hydrochloride |
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| HY-15430A | MedChemExpress | 10mM/1mL | EUR 482 |
ZM323881 (hydrochloride) |
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| HY-15467A | MedChemExpress | 50mg | EUR 691 |
OTSSP167 (hydrochloride) |
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| HY-15512A | MedChemExpress | 50mg | EUR 1083 |
Piboserod (hydrochloride) |
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| HY-15574A | MedChemExpress | 50mg | EUR 670 |
MMAF (Hydrochloride) |
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| HY-15579A | MedChemExpress | 10mM/1mL | EUR 562 |
Taltobulin (hydrochloride) |
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| HY-15584B | MedChemExpress | 50mg | EUR 1025 |
AZD1208 hydrochloride |
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| HY-15604A | MedChemExpress | 10mg | EUR 167 |
MPTP (hydrochloride) |
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| HY-15608 | MedChemExpress | 50mg | EUR 257 |
SC144 (hydrochloride) |
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| HY-15614A | MedChemExpress | 25mg | EUR 245 |
SAR407899 (hydrochloride) |
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| HY-15687 | MedChemExpress | 10mM/1mL | EUR 126 |
SAR7334 (hydrochloride) |
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| HY-15699A | MedChemExpress | 10mM/1mL | EUR 475 |
Istaroxime (hydrochloride) |
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| HY-15718A | MedChemExpress | 50mg | EUR 1207 |
Afuresertib (hydrochloride) |
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| HY-15727A | MedChemExpress | 5mg | EUR 147 |
Dobutamine (hydrochloride) |
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| HY-15746 | MedChemExpress | 100mg | EUR 215 |
Deltarasin (hydrochloride) |
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| HY-15747A | MedChemExpress | 10mg | EUR 340 |
Ellipticine (hydrochloride) |
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| HY-15753A | MedChemExpress | 10mM/1mL | EUR 126 |
Tirabrutinib (hydrochloride) |
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| HY-15771A | MedChemExpress | 5mg | EUR 108 |
CBB1003 (hydrochloride) |
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| HY-15774A | MedChemExpress | 50mg | EUR 2116 |