Cell culture-derived influenza vaccines in the severe 2017-2018 epidemic season: a step towards improved influenza vaccine effectiveness.

The 2017-2018 seasonal influenza epidemics are severe in the US and Australia where A (H3N2) virus subtype dominated. Although circulating A (H3N2) virus antigen is not different from that recommended by the WHO for vaccine production, the overall interim estimate of vaccine effectiveness was under the historical average (33%) for A (H3N2) virus. The majority (USA) or all (Australia) dose of vaccine contains several amino acid changes in the hemagglutinin protein, which is produced from the necessary adaptation of the virus to embryonated chicken eggs used to manufacture the vaccine most. Previous reports have suggested the potential negative impact of the substitution of egg-driven performance of the vaccine. With the support of Barda, two vaccines licensed in the US is produced in cell culture: a recombinant influenza vaccine (RIV, Flublok ™) produced in insect cells and inactivated vaccines adult mammalian cells (ccIIV, Flucelvax ™). CcIIV quadrivalent (ccIIV4) vaccine for the 2017-2018 influenza season was produced using seed virus A (H3N2) distributed exclusively in cell culture and therefore less adaptative changes eggs. ccIIV dose fairly distributed (but not RIV dose) to allow the initial estimates of higher efficacy relative to traditional egg-based vaccine, the study details pending. The increased availability of certain product comparison vaccine effectiveness estimates for cell-based vaccine and egg-based can provide important clues to inform vaccine product improvements moving forward.

Diclofenac Diethylamine

B1928-50 50 mg
EUR 128
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Diethylamine

B1928-S Evaluation Sample
EUR 81
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Sarafloxacin Hydrochloride

S003-25G 25 g
EUR 168

Sarafloxacin Hydrochloride

S003-5G 5 g
EUR 74

Sancycline hydrochloride

S076-10MG 10 mg
EUR 128

Sancycline hydrochloride

S076-50MG 50 mg
EUR 440

Moxifloxacin Hydrochloride

M033-100MG 100 mg
EUR 129

Moxifloxacin Hydrochloride

M033-500MG 500 mg
EUR 424

Metformin hydrochloride

M087-1G 1 g
EUR 47

Metformin hydrochloride

M087-5G 5 g
EUR 52

Naftifine hydrochloride

N047-500MG 500 mg
EUR 709

Naftifine hydrochloride

N047-50MG 50 mg
EUR 138

Oxytetracycline Hydrochloride

O004-100G 100 g
EUR 171

Oxytetracycline Hydrochloride

O004-10G 10 g
EUR 66

Oxytetracycline Hydrochloride

O004-50G 50 g
EUR 114

Ofloxacin Hydrochloride

O039-10G 10g
EUR 163

Lomefloxacin hydrochloride

L005-1G 1 g
EUR 74

Lomefloxacin hydrochloride

L005-5G 5 g
EUR 153

Methacycline hydrochloride

M003-100MG 100 mg
EUR 139

Methacycline hydrochloride

M003-1G 1 g
EUR 187

Minocycline hydrochloride

M008-1G 1 g
EUR 347

Minocycline hydrochloride

M008-500MG 500 mg
EUR 200

Mitoxantrone hydrochloride

M010-50MG 50 mg
EUR 129

Pirlimycin Hydrochloride

P088-25MG 25 mg
EUR 670

Pirlimycin Hydrochloride

P088-5MG 5 mg
EUR 213

Ofloxacin Hydrochloride

O039-1G 1g
EUR 63

Tasidotin hydrochloride

HY-13760 5mg
EUR 2198

Topotecan (Hydrochloride)

HY-13768A 10mg
EUR 119

Hydroxyfasudil (hydrochloride)

HY-13911A 10mM/1mL
EUR 168

Sevelamer hydrochloride

HY-13995A 100mg
EUR 153

Rimonabant (Hydrochloride)

HY-14137 100mg
EUR 463

Cinaciguat (hydrochloride)

HY-14181A 50mg
EUR 1290

Vernakalant (Hydrochloride)

HY-14183 5mg
EUR 366

Amiodarone (hydrochloride)

HY-14188 500mg
EUR 108

Clorgyline hydrochloride

HY-14197A 100mg
EUR 380

Siramesine (hydrochloride)

HY-14221A 50mg
EUR 1290

Fadrozole hydrochloride

HY-14247 100mg
EUR 614

Olprinone (Hydrochloride)

HY-14254 50mg
EUR 452

Vilazodone (Hydrochloride)

HY-14261 10mg
EUR 119

Tebanicline (hydrochloride)

HY-14316A 100mg
EUR 1069

Idalopirdine Hydrochloride

HY-14338A 50mg
EUR 1297

Haloperidol (hydrochloride)

HY-14538A 500mg
EUR 160

Ziprasidone (hydrochloride)

HY-14542A 50mg
EUR 277

Amisulpride (hydrochloride)

HY-14545A 100mg
EUR 160

Talnetant (hydrochloride)

HY-14552A 10mg
EUR 236

Idazoxan (hydrochloride)

HY-14561A 50mg
EUR 136

Pioglitazone (hydrochloride)

HY-14601 100mg
EUR 119

MPEP (Hydrochloride)

HY-14609 50mg
EUR 366

Diltiazem (hydrochloride)

HY-14656 1g
EUR 119

CCT241533 (hydrochloride)

HY-14715B 100mg
EUR 1745

Resminostat (hydrochloride)

HY-14718A 10mM/1mL
EUR 307

Anamorelin (hydrochloride)

HY-14734A 5mg
EUR 147

Golotimod (hydrochloride)

HY-14743B 5mg
EUR 452

Cariprazine (hydrochloride)

HY-14763A 5mg
EUR 215

Imeglimin (hydrochloride)

HY-14771A 10mM/1mL
EUR 429

Befiradol (hydrochloride)

HY-14785A 10mM/1mL
EUR 744

Givinostat (hydrochloride)

HY-14842A 100mg
EUR 1703

Lasmiditan (hydrochloride)

HY-14861A 100mg
EUR 796

Omadacycline (hydrochloride)

HY-14865C 50mg
EUR 2116

Fabomotizole (hydrochloride)

HY-14895A 100mg
EUR 1714

Arbidol (hydrochloride)

HY-14904A 50mg
EUR 298

Migalastat (hydrochloride)

HY-14929A 25mg
EUR 587

Pardoprunox (hydrochloride)

HY-14958A 100mg
EUR 2943

R1487 (Hydrochloride)

HY-14975 100mg
EUR 1139

Sinomenine hydrochloride

HY-15122A 100mg
EUR 119

Doxorubicin (hydrochloride)

HY-15142 100mg
EUR 147

SBE13 (Hydrochloride)

HY-15158 10mg
EUR 162

Icotinib (Hydrochloride)

HY-15164 10mM/1mL
EUR 138

Pyridostatin (hydrochloride)

HY-15176A 10mg
EUR 195

Buparlisib (Hydrochloride)

HY-15180 10mg
EUR 173

Agerafenib hydrochloride

HY-15199 100mg
EUR 1703

EPZ004777 (hydrochloride)

HY-15227A 10mg
EUR 312

XL413 (hydrochloride)

HY-15260A 5mg
EUR 215

Prasugrel (hydrochloride)

HY-15284A 100mg
EUR 326

S107 hydrochloride

HY-15292A 50mg
EUR 670

CBB1007 (hydrochloride)

HY-15313B 100mg
EUR 1882

PRT062607 (Hydrochloride)

HY-15323 10mM/1mL
EUR 229

Atrasentan (hydrochloride)

HY-15403A 10mM/1mL
EUR 349

Encenicline hydrochloride

HY-15430A 10mM/1mL
EUR 482

ZM323881 (hydrochloride)

HY-15467A 50mg
EUR 691

OTSSP167 (hydrochloride)

HY-15512A 50mg
EUR 1083

Piboserod (hydrochloride)

HY-15574A 50mg
EUR 670

MMAF (Hydrochloride)

HY-15579A 10mM/1mL
EUR 562

Taltobulin (hydrochloride)

HY-15584B 50mg
EUR 1025

AZD1208 hydrochloride

HY-15604A 10mg
EUR 167

MPTP (hydrochloride)

HY-15608 50mg
EUR 257

SC144 (hydrochloride)

HY-15614A 25mg
EUR 245

SAR407899 (hydrochloride)

HY-15687 10mM/1mL
EUR 126

SAR7334 (hydrochloride)

HY-15699A 10mM/1mL
EUR 475

Istaroxime (hydrochloride)

HY-15718A 50mg
EUR 1207

Afuresertib (hydrochloride)

HY-15727A 5mg
EUR 147

Dobutamine (hydrochloride)

HY-15746 100mg
EUR 215

Deltarasin (hydrochloride)

HY-15747A 10mg
EUR 340

Ellipticine (hydrochloride)

HY-15753A 10mM/1mL
EUR 126

Tirabrutinib (hydrochloride)

HY-15771A 5mg
EUR 108

CBB1003 (hydrochloride)

HY-15774A 50mg
EUR 2116