3A Plastik

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Cell culture-derived influenza vaccines in the severe 2017-2018 epidemic season: a step towards improved influenza vaccine effectiveness.

The 2017-2018 seasonal influenza epidemics are severe in the US and Australia where A (H3N2) virus subtype dominated. Although circulating A (H3N2) virus antigen is not different from that recommended by the WHO for vaccine production, the overall interim estimate of vaccine effectiveness was under the historical average (33%) for A (H3N2) virus. The majority (USA) or all (Australia) dose of vaccine contains several amino acid changes in the hemagglutinin protein, which is produced from the necessary adaptation of the virus to embryonated chicken eggs used to manufacture the vaccine most. Previous reports have suggested the potential negative impact of the substitution of egg-driven performance of the vaccine. With the support of Barda, two vaccines licensed in the US is produced in cell culture: a recombinant influenza vaccine (RIV, Flublok ™) produced in insect cells and inactivated vaccines adult mammalian cells (ccIIV, Flucelvax ™). CcIIV quadrivalent (ccIIV4) vaccine for the 2017-2018 influenza season was produced using seed virus A (H3N2) distributed exclusively in cell culture and therefore less adaptative changes eggs. ccIIV dose fairly distributed (but not RIV dose) to allow the initial estimates of higher efficacy relative to traditional egg-based vaccine, the study details pending. The increased availability of certain product comparison vaccine effectiveness estimates for cell-based vaccine and egg-based can provide important clues to inform vaccine product improvements moving forward.

Diethylamine
GK3170-100 100
EUR 18.1

DIETHYLAMINE PHOSPHATE
504015 each Ask for price

Diclofenac diethylamine
20-abx185392
  • EUR 510.00
  • EUR 292.80
  • 25 g
  • 5 g

Diclofenac Diethylamine
B1928-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Diethylamine
B1928-50 50 mg
EUR 153.6
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Diethylamine
B1928-S Evaluation Sample
EUR 97.2
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac (diethylamine)
HY-15036A 10mM/1mL
EUR 135.6

Diethylamino hydroxybenzoyl hexyl benzoate
HY-109656 100mg
EUR 142.8

3-Diethylaminophenol
GK1051-25G 25 g
EUR 84

3-Diethylaminophenol
GK1051-25 25
EUR 39.4

4-(Diethylamino)butylamine
20-abx180467
  • EUR 326.40
  • EUR 1395.60
  • EUR 594.00
  • 1 g
  • 25 g
  • 5 g

3-Diethylamino-1-Propanol
20-abx181113
  • EUR 577.20
  • EUR 343.20
  • EUR 243.60
  • 100 g
  • 25 g
  • 5 g

2‐AMINO ACETAMIDE HYDROCHLORIDE (GLYCINAMIDE HYDROCHLORIDE)
101003 each Ask for price

5-Diethylamino-2-Pentanone
abx188533-500g 500 g
EUR 2064

4,4'-Bis(diethylamino)benzophenone
GX2406-100G 100 g
EUR 96

4,4''-Bis(diethylamino)benzophenone
GX2406-100 100
EUR 49.9

4-(Diethylamino)salicylaldehyde
20-abx184588
  • EUR 260.40
  • EUR 427.20
  • 100 g
  • 500 g

DiEthylAmino Magnetic Particles
DEM-30-10 10 mL
EUR 261.6
Description: DiEthylAmino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

7-(Diethylamino)-3-phenylcoumarin
GT7462-10G 10 g
EUR 428.4

7-(Diethylamino)-3-phenylcoumarin
GT7462-1G 1 g
EUR 112.8

7-(Diethylamino)-3-phenylcoumarin
GT7462-5G 5 g
EUR 265.2

7-(Diethylamino)-3-phenylcoumarin
GT7462-1 1
EUR 63.3

7-(Diethylamino)-3-phenylcoumarin
GT7462-10 10
EUR 324.2

7-(Diethylamino)-3-phenylcoumarin
GT7462-5 5
EUR 189.8

DOI hydrochloride
B5321-10 10 mg
EUR 205.2

DOI hydrochloride
B5321-5 5 mg
EUR 141.6

DOI hydrochloride
B5321-50 50 mg
EUR 714

DOB hydrochloride
B5344-1 1 mg
EUR 141.6

Q94 hydrochloride
B5705-10 10 mg
EUR 350.4

Q94 hydrochloride
B5705-50 50 mg
EUR 1264.8

GMQ hydrochloride
B5793-10 10 mg
EUR 212.4

GMQ hydrochloride
B5793-50 50 mg
EUR 711.6

AMT hydrochloride
B6480-10 10 mg
EUR 205.2

AMT hydrochloride
B6480-100 100 mg
EUR 1036.8

AMT hydrochloride
B6480-5 5 mg
EUR 141.6

AMT hydrochloride
B6480-50 50 mg
EUR 673.2

BEC (hydrochloride)
HY-19548A 25mg
EUR 570

EDC hydrochloride
GP0849-100G 100 g
EUR 141.6

EDC hydrochloride
GP0849-250G 250 g
EUR 237.6

EDC hydrochloride
GP0849-25G 25 g
EUR 84

EDC hydrochloride
GP0849-5G 5 g
EUR 55.2

SAG (hydrochloride)
HY-12848B 10mg
EUR 321.6

EDC hydrochloride
GP0849-100 100
EUR 87.1

EDC hydrochloride
GP0849-25 25
EUR 39.4

EDC hydrochloride
GP0849-250 250
EUR 166

EDC hydrochloride
GP0849-5 5
EUR 15.9

AMTB hydrochloride
B2978-25 25 mg
EUR 812.4

AMTB hydrochloride
B2978-5 5 mg
EUR 247.2

MPEP hydrochloride
B1151-10 each
EUR 222

MPEP hydrochloride
B1151-50 each
EUR 705.6

S1RA hydrochloride
B1180-10 10 mg
EUR 1144.8
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-100 100 mg
EUR 4620
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-5 5 mg
EUR 819.6
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-5.1 10 mM (in 1mL DMSO)
EUR 895.2
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-50 50 mg
EUR 3316.8
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

THZ1 Hydrochloride
B4736-10 10 mg
EUR 268.8
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-25 25 mg
EUR 477.6
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-5 5 mg
EUR 170.4
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-5.1 10 mM (in 1mL DMSO)
EUR 205.2
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

EHNA hydrochloride
2265-25 each
EUR 339.6

EHNA hydrochloride
2265-5 each
EUR 138

TAME Hydrochloride
2050-100 each
EUR 151.2

TAME Hydrochloride
2050-1000 each
EUR 574.8

TAME Hydrochloride
2050-500 each
EUR 405.6

DMCM hydrochloride
B7268-10 10 mg
EUR 385.2

DMCM hydrochloride
B7268-100 100 mg
EUR 2210.4

DMCM hydrochloride
B7268-25 25 mg
EUR 776.4

DMCM hydrochloride
B7268-5 5 mg
EUR 277.2

DMCM hydrochloride
B7268-5.1 10 mM (in 1mL H2O)
EUR 297.6

DMCM hydrochloride
B7268-50 50 mg
EUR 1363.2

TRIS hydrochloride
B7299-500000 500 g
EUR 309.6

AMTB hydrochloride
B7559-10 10 mg
EUR 459.6

AMTB hydrochloride
B7559-50 50 mg
EUR 1746

MPEP Hydrochloride
A3633-10 10 mg
EUR 142.8
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system.

MPEP Hydrochloride
A3633-50 50 mg
EUR 379.2
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system.

MPTP hydrochloride
A3634-10 10 mg
EUR 162
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1].

MPTP hydrochloride
A3634-50 50 mg
EUR 344.4
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1].

MTEP hydrochloride
A3636-10 10 mg
EUR 205.2
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

MTEP hydrochloride
A3636-5 5 mg
EUR 153.6
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

MTEP hydrochloride
A3636-50 50 mg
EUR 686.4
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

PJ34 hydrochloride
A4159-10 10 mg
EUR 142.8
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-5 5 mg
EUR 129.6
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-5.1 10 mM (in 1mL DMSO)
EUR 150
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-50 50 mg
EUR 296.4
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-S Evaluation Sample
EUR 97.2
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

TCEP hydrochloride
B6055-10000 10 g
EUR 338.4
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride
B6055-2000 2 g
EUR 150
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride
B6055-50000 50 g
EUR 1243.2
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

HEAT hydrochloride
B6339-10 10 mg
EUR 321.6

HEAT hydrochloride
B6339-50 50 mg
EUR 1167.6

THIP hydrochloride
B6460-100 100 mg
EUR 358.8

THIP hydrochloride
B6460-25 25 mg
EUR 174

THIP hydrochloride
B6460-50 50 mg
EUR 243.6

EHNA hydrochloride
B6662-10 10 mg
EUR 145.2

EHNA hydrochloride
B6662-25 25 mg
EUR 262.8

N20C hydrochloride
B6980-10 10 mg
EUR 340.8

N20C hydrochloride
B6980-50 50 mg
EUR 1245.6

TMPH hydrochloride
B7053-10 10 mg
EUR 321.6

TMPH hydrochloride
B7053-50 50 mg
EUR 1167.6

DAPI (hydrochloride)
C3362-10 10 mg
EUR 146.4

DAPI (hydrochloride)
C3362-25 25 mg
EUR 240

DAPI (hydrochloride)
C3362-5 5 mg
EUR 111.6

AD57 (hydrochloride)
C3080-1 1 mg
EUR 141.6
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)
C3080-10 10 mg
EUR 714
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)
C3080-5 5 mg
EUR 428.4
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

MMAD hydrochloride
ADC-P-019 unit Ask for price

MMAF Hydrochloride
ADC-P-021 unit Ask for price

THZ1 hydrochloride
9544-25 each
EUR 1227.6

THZ1 hydrochloride
9544-5 each
EUR 366

TRIS hydrochloride
GB4431-100G 100 g
EUR 64.8

TRIS hydrochloride
GB4431-1KG 1 kg
EUR 160.8

TRIS hydrochloride
GB4431-250G 250 g
EUR 76.8

TRIS hydrochloride
GB4431-500G 500 g
EUR 103.2

TRIS hydrochloride
GB4431-5KG 5 kg
EUR 486

EDAC, hydrochloride
EB0433 25g
EUR 123.68

TCEP (hydrochloride)
HY-W011500 10mM/1mL
EUR 135.6

MCLA hydrochloride
HY-W013275 5mg
EUR 381.6

DMCM (hydrochloride)
HY-100369A 100mg
EUR 1695.6

OABK (hydrochloride)
HY-100825 100mg
EUR 3531.6

EIPA (hydrochloride)
HY-101840A 10mM/1mL
EUR 151.2

(±)-ANAP hydrochloride
HY-101937C 5mg
EUR 817.2

EHNA (hydrochloride)
HY-103160A 5mg
EUR 170.4

MMAF (Hydrochloride)
HY-15579A 10mM/1mL
EUR 674.4

MPTP (hydrochloride)
HY-15608 50mg
EUR 308.4

K145 (hydrochloride)
HY-15779A 10mM/1mL
EUR 169.2

S1RA (hydrochloride)
HY-18099A 10mM/1mL
EUR 696

THZ1 (Hydrochloride)
HY-80013A 5mg
EUR 192

TAME Hydrochloride
GM4942-5G 5 g
EUR 90

ACHP (Hydrochloride)
HY-13060 100mg
EUR 1861.2

MTEP (hydrochloride)
HY-13206 10mg
EUR 200.4

TAME hydrochloride
HY-13255A 100mg
EUR 192

PJ34 (hydrochloride)
HY-13688 10mg
EUR 159.6

MPEP (Hydrochloride)
HY-14609 50mg
EUR 439.2

S107 hydrochloride
HY-15292A 50mg
EUR 804

TCEP hydrochloride
TB0974 1g
EUR 101.76

Tris hydrochloride
TB0103 250g
EUR 84.01

TRIS hydrochloride
GB4431-1 1
EUR 102.7

TRIS hydrochloride
GB4431-100 100
EUR 23.8

TRIS hydrochloride
GB4431-250 250
EUR 34.1

TRIS hydrochloride
GB4431-5 5
EUR 371.8

TRIS hydrochloride
GB4431-500 500
EUR 55.4

TAME Hydrochloride
GM4942-5 5
EUR 45.1

Diethylaminosulfur trifluoride
20-abx180722
  • EUR 678.00
  • EUR 360.00
  • EUR 2214.00
  • EUR 260.40
  • 100 g
  • 25 g
  • 500 g
  • 5 g

4''-Diethylamino-3-hydroxyflavone
GW8878-100 100
EUR 537.5

4''-Diethylamino-3-hydroxyflavone
GW8878-50 50
EUR 327

CPTH2 (hydrochloride)
B2815-1 each
EUR 144

CPTH2 (hydrochloride)
B2815-5 each
EUR 352.8

XL413 hydrochloride
B1015-10 10 mg
EUR 289.2
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride
B1015-100 100 mg
EUR 1005.6
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride
B1015-5 5 mg
EUR 205.2
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

XL413 hydrochloride
B1015-50 50 mg
EUR 714
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1

SMANT hydrochloride
B5674-10 10 mg
EUR 350.4

SMANT hydrochloride
B5674-50 50 mg
EUR 1284

SBE13 hydrochloride
2847-10 each
EUR 222

SBE13 hydrochloride
2847-50 each
EUR 705.6

MS049 (hydrochloride)
C3776-10 10 mg
EUR 240
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-100 100 mg
EUR 1417.2
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-25 25 mg
EUR 458.4
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-5 5 mg
EUR 166.8
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-5.1 10 mM (in 1mL DMSO)
EUR 180
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-50 50 mg
EUR 783.6
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

VU590 (hydrochloride)
C4778-10 10 mg
EUR 234

VU590 (hydrochloride)
C4778-25 25 mg
EUR 466.8

VU590 (hydrochloride)
C4778-5 5 mg
EUR 166.8

MMPIP hydrochloride
B7234-1 1 mg
EUR 151.2

MMPIP hydrochloride
B7234-10 10 mg
EUR 308.4