Cell culture-derived influenza vaccines in the severe 2017-2018 epidemic season: a step towards improved influenza vaccine effectiveness.

The 2017-2018 seasonal influenza epidemics are severe in the US and Australia where A (H3N2) virus subtype dominated. Although circulating A (H3N2) virus antigen is not different from that recommended by the WHO for vaccine production, the overall interim estimate of vaccine effectiveness was under the historical average (33%) for A (H3N2) virus. The majority (USA) or all (Australia) dose of vaccine contains several amino acid changes in the hemagglutinin protein, which is produced from the necessary adaptation of the virus to embryonated chicken eggs used to manufacture the vaccine most. Previous reports have suggested the potential negative impact of the substitution of egg-driven performance of the vaccine. With the support of Barda, two vaccines licensed in the US is produced in cell culture: a recombinant influenza vaccine (RIV, Flublok ™) produced in insect cells and inactivated vaccines adult mammalian cells (ccIIV, Flucelvax ™). CcIIV quadrivalent (ccIIV4) vaccine for the 2017-2018 influenza season was produced using seed virus A (H3N2) distributed exclusively in cell culture and therefore less adaptative changes eggs. ccIIV dose fairly distributed (but not RIV dose) to allow the initial estimates of higher efficacy relative to traditional egg-based vaccine, the study details pending. The increased availability of certain product comparison vaccine effectiveness estimates for cell-based vaccine and egg-based can provide important clues to inform vaccine product improvements moving forward.

Diclofenac Diethylamine
B1928-50	ApexBio	50 mg	EUR 153.6
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Diethylamine
B1928-S	ApexBio	Evaluation Sample	EUR 97.2
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac (diethylamine)
HY-15036A	MedChemExpress	10mM/1mL	EUR 135.6

Tetracycline, Hydrochloride
CH054	ABM	25 g	EUR 142.8

Tetracycline, Hydrochloride
CH055	ABM	100 g	EUR 204

Ciprofloxacin hydrochloride
C032-25G	TOKU-E	25 g	EUR 199.2

Ciprofloxacin hydrochloride
C032-5G	TOKU-E	5 g	EUR 74.4

Clindamycin Hydrochloride
C035-100MG	TOKU-E	100 mg	EUR 243.6

Clindamycin Hydrochloride
C035-50MG	TOKU-E	50 mg	EUR 152.4

Chlortetracycline Hydrochloride
C072-100G	TOKU-E	100 g	EUR 376.8

Chlortetracycline Hydrochloride
C072-25G	TOKU-E	25 g	EUR 157.2

Chlortetracycline Hydrochloride
C072-5G	TOKU-E	5 g	EUR 78

Cefozopran Hydrochloride
C099-100MG	TOKU-E	100 mg	EUR 300

Cysteamine hydrochloride
C212-25G	TOKU-E	25 g	EUR 78

Cysteamine hydrochloride
C212-4x25G	TOKU-E	4 x 25 g	EUR 154.8

Ceftiofur Hydrochloride
C228-1G	TOKU-E	1 g	EUR 129.6

Ceftiofur Hydrochloride
C228-5G	TOKU-E	5 g	EUR 387.6

Cefmenoxime Hydrochloride
C240-100MG	TOKU-E	100mg	EUR 136.8

Cefmenoxime Hydrochloride
C240-500MG	TOKU-E	500mg	EUR 334.8

Cinacalcet Hydrochloride
C242-100MG	TOKU-E	100mg	EUR 513.6

Cinacalcet Hydrochloride
C242-10MG	TOKU-E	10mg	EUR 94.8

Enrofloxacin hydrochloride
E007-100MG	TOKU-E	100 mg	EUR 147.6

Enrofloxacin hydrochloride
E007-1G	TOKU-E	1 g	EUR 776.4

Enrofloxacin hydrochloride
E007-500MG	TOKU-E	500 mg	EUR 475.2

Erlotinib hydrochloride
E017-100MG	TOKU-E	100 mg	EUR 136.8

Erlotinib hydrochloride
E017-1G	TOKU-E	1 g	EUR 373.2

Pazopanib Hydrochloride
A8347-100	ApexBio	100 mg	EUR 268.8
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

Pazopanib Hydrochloride
A8347-25	ApexBio	25 mg	EUR 129.6
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

Pazopanib Hydrochloride
A8347-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 135.6
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

Pazopanib Hydrochloride
A8347-500	ApexBio	500 mg	EUR 727.2
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

Pazopanib Hydrochloride
A8347-S	ApexBio	Evaluation Sample	EUR 97.2
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3].

Bestatin hydrochloride
A8621-10	ApexBio	10 mg	EUR 157.2
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity.

Bestatin hydrochloride
A8621-100	ApexBio	100 mg	EUR 532.8
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity.

Bestatin hydrochloride
A8621-25	ApexBio	25 mg	EUR 226.8
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity.

Bestatin hydrochloride
A8621-5	ApexBio	5 mg	EUR 129.6
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity.

Flavopiridol hydrochloride
A8640-10	ApexBio	10 mg	EUR 129.6
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

Flavopiridol hydrochloride
A8640-100	ApexBio	100 mg	EUR 528
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

Flavopiridol hydrochloride
A8640-1000	ApexBio	1 g	EUR 3259.2
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

Flavopiridol hydrochloride
A8640-25	ApexBio	25 mg	EUR 199.2
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

Flavopiridol hydrochloride
A8640-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 129.6
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle.

Regorafenib hydrochloride
A3750-10	ApexBio	10 mg	EUR 150
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

Regorafenib hydrochloride
A3750-100	ApexBio	100 mg	EUR 282
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

Regorafenib hydrochloride
A3750-200	ApexBio	200 mg	EUR 582
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

Regorafenib hydrochloride
A3750-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 199.2
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

Regorafenib hydrochloride
A3750-50	ApexBio	50 mg	EUR 199.2
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

Resminostat hydrochloride
A3755-10	ApexBio	10 mg	EUR 428.4
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

Resminostat hydrochloride
A3755-100	ApexBio	100 mg	EUR 1905.6
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

Resminostat hydrochloride
A3755-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 464.4
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

Resminostat hydrochloride
A3755-50	ApexBio	50 mg	EUR 1209.6
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

Rimonabant hydrochloride
A3766-10	ApexBio	10 mg	EUR 186
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug.

Rimonabant hydrochloride
A3766-100	ApexBio	100 mg	EUR 710.4
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug.

Rimonabant hydrochloride
A3766-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 199.2
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug.

Rimonabant hydrochloride
A3766-50	ApexBio	50 mg	EUR 494.4
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug.

Rotigotine hydrochloride
A3777-100	ApexBio	100 mg	EUR 480
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

Rotigotine hydrochloride
A3777-200	ApexBio	200 mg	EUR 812.4
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

Rotigotine hydrochloride
A3777-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 417.6
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

Rotigotine hydrochloride
A3777-50	ApexBio	50 mg	EUR 360
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

Rotigotine hydrochloride
A3777-500	ApexBio	500 mg	EUR 1663.2
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

Tipiracil hydrochloride
A3875-10	ApexBio	10 mg	EUR 553.2
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Tipiracil hydrochloride
A3875-25	ApexBio	25 mg	EUR 774
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Tipiracil hydrochloride
A3875-5	ApexBio	5 mg	EUR 382.8
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Tipiracil hydrochloride
A3875-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 351.6
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Tipiracil hydrochloride
A3875-50	ApexBio	50 mg	EUR 1230
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway.

Vandetanib hydrochloride
A3906-100	ApexBio	100 mg	EUR 517.2
Description: Description: IC50 Value: 40 nM (VEGFR2) [1]; 500 nM (EGFR) [2] Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland.

Vandetanib hydrochloride
A3906-25	ApexBio	25 mg	EUR 201.6
Description: Description: IC50 Value: 40 nM (VEGFR2) [1]; 500 nM (EGFR) [2] Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland.

Vernakalant Hydrochloride
A3915-10	ApexBio	10 mg	EUR 847.2
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization.

Vernakalant Hydrochloride
A3915-100	ApexBio	100 mg	EUR 3316.8
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization.

Vernakalant Hydrochloride
A3915-50	ApexBio	50 mg	EUR 2090.4
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization.

Vilazodone Hydrochloride
A3919-10	ApexBio	10 mg	EUR 129.6
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

Vilazodone Hydrochloride
A3919-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 129.6
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

Vilazodone Hydrochloride
A3919-50	ApexBio	50 mg	EUR 157.2
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

Voreloxin Hydrochloride
A3925-10	ApexBio	10 mg	EUR 895.2
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication.

Voreloxin Hydrochloride
A3925-5	ApexBio	5 mg	EUR 656.4
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication.

Voreloxin Hydrochloride
A3925-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 717.6
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication.

PJ34 hydrochloride
A4159-10	ApexBio	10 mg	EUR 142.8
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-5	ApexBio	5 mg	EUR 129.6
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 150
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-50	ApexBio	50 mg	EUR 296.4
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-S	ApexBio	Evaluation Sample	EUR 97.2
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

Dimethylamine hydrochloride
DB0410	Bio Basic	500g	EUR 116.38

Daunorubicin hydrochloride
D001-10MG	TOKU-E	10 mg	EUR 142.8

Daunorubicin hydrochloride
D001-50MG	TOKU-E	50 mg	EUR 480

Difloxacin hydrochloride
D021-1G	TOKU-E	1 g	EUR 133.2

Difloxacin hydrochloride
D021-5G	TOKU-E	5 g	EUR 438

Demeclocycline hydrochloride
D032-1G	TOKU-E	1 g	EUR 208.8

Demeclocycline hydrochloride
D032-250MG	TOKU-E	250 mg	EUR 105.6

Demeclocycline hydrochloride
D032-5G	TOKU-E	5 g	EUR 646.8

Doxycycline Hydrochloride
D065-25MG	TOKU-E	25mg	EUR 410.4

Doxycycline Hydrochloride
D065-5MG	TOKU-E	5mg	EUR 142.8

Dalbavancin Hydrochloride
D092-10MG	TOKU-E	10mg	EUR 152.4

Dalbavancin Hydrochloride
D092-50MG	TOKU-E	50mg	EUR 456

Cefepime Hydrochloride
C009-100MG	TOKU-E	100 mg	EUR 320.4

Ceftazidime Hydrochloride
C020-1G	TOKU-E	1 g	EUR 746.4

Niguldipine (hydrochloride)
C3067-10	ApexBio	10 mg	EUR 164.4
Description: Ki = 0.16 nM: ?1A-adrenoceptor antagonistIC50s = 0.4 ?M: inhibits L-type Ca2+ channelsIC50s = 0.9 ?M: suppresses T-type Ca2+ channelsNiguldipine is a less potent Ca2+ channel blocker and potent, selective ?1A-adrenoceptor receptor antagonist.

Niguldipine (hydrochloride)
C3067-25	ApexBio	25 mg	EUR 308.4
Description: Ki = 0.16 nM: ?1A-adrenoceptor antagonistIC50s = 0.4 ?M: inhibits L-type Ca2+ channelsIC50s = 0.9 ?M: suppresses T-type Ca2+ channelsNiguldipine is a less potent Ca2+ channel blocker and potent, selective ?1A-adrenoceptor receptor antagonist.

AD57 (hydrochloride)
C3080-1	ApexBio	1 mg	EUR 141.6
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)
C3080-10	ApexBio	10 mg	EUR 714
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)
C3080-5	ApexBio	5 mg	EUR 428.4
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

Pargyline (hydrochloride)
C3106-1000	ApexBio	1 g	EUR 139.2
Description: IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).IC50: 8.2 nM: blocks MAO type B (MAO-B).Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells.

Pargyline (hydrochloride)
C3106-5000	ApexBio	5 g	EUR 410.4
Description: IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).IC50: 8.2 nM: blocks MAO type B (MAO-B).Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells.

Clenbuterol (hydrochloride)
C3119-100	ApexBio	100 mg	EUR 258
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

Clenbuterol (hydrochloride)
C3119-25	ApexBio	25 mg	EUR 130.8
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

Clenbuterol (hydrochloride)
C3119-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 135.6
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

Clenbuterol (hydrochloride)
C3119-50	ApexBio	50 mg	EUR 189.6
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.

CBL0137 (hydrochloride)
C3192-10	ApexBio	10 mg	EUR 529.2
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)
C3192-25	ApexBio	25 mg	EUR 1071.6
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)
C3192-5	ApexBio	5 mg	EUR 331.2
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)
C3192-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 282
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CBL0137 (hydrochloride)
C3192-50	ApexBio	50 mg	EUR 1851.6
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B.

CPTH2 (hydrochloride)
C3208-10	ApexBio	10 mg	EUR 231.6
Description: CPTH2 is an inhibitor of HAT activity of Gcn5.

CPTH2 (hydrochloride)
C3208-5	ApexBio	5 mg	EUR 192
Description: CPTH2 is an inhibitor of HAT activity of Gcn5.

Clinafloxacin (hydrochloride)
C3345-100	ApexBio	100 mg	EUR 184.8
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Clinafloxacin (hydrochloride)
C3345-1000	ApexBio	1 g	EUR 686.4
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Clinafloxacin (hydrochloride)
C3345-250	ApexBio	250 mg	EUR 309.6
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Clinafloxacin (hydrochloride)
C3345-500	ApexBio	500 mg	EUR 459.6
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Isoxsuprine (hydrochloride)
C3347-10000	ApexBio	10 g	EUR 145.2
Description: Isoxsuprine is a modulator of ?2 adrenoreceptor and has agonist or antagonist effects.The ?2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine.

Isoxsuprine (hydrochloride)
C3347-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 135.6
Description: Isoxsuprine is a modulator of ?2 adrenoreceptor and has agonist or antagonist effects.The ?2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine.

DAPI (hydrochloride)
C3362-10	ApexBio	10 mg	EUR 146.4

DAPI (hydrochloride)
C3362-25	ApexBio	25 mg	EUR 240

DAPI (hydrochloride)
C3362-5	ApexBio	5 mg	EUR 111.6

Kanosamine (hydrochloride)
C3461-10	ApexBio	10 mg	EUR 528
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested.

Kanosamine (hydrochloride)
C3461-25	ApexBio	25 mg	EUR 1089.6
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested.

Kanosamine (hydrochloride)
C3461-5	ApexBio	5 mg	EUR 324
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested.

Zoniporide (hydrochloride)
C3480-10	ApexBio	10 mg	EUR 278.4
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types.

Zoniporide (hydrochloride)
C3480-5	ApexBio	5 mg	EUR 181.2
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types.

Zoniporide (hydrochloride)
C3480-50	ApexBio	50 mg	EUR 1004.4
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types.

MS023 (hydrochloride)
C3503-1	ApexBio	1 mg	EUR 134.4
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)
C3503-10	ApexBio	10 mg	EUR 661.2
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)
C3503-25	ApexBio	25 mg	EUR 1375.2
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

MS023 (hydrochloride)
C3503-5	ApexBio	5 mg	EUR 398.4
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes.

Chlorprothixene (hydrochloride)
C3509-1000	ApexBio	1 g	EUR 103.2
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)
C3509-10000	ApexBio	10 g	EUR 397.2
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)
C3509-25000	ApexBio	25 g	EUR 796.8
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)
C3509-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 135.6
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Chlorprothixene (hydrochloride)
C3509-5000	ApexBio	5 g	EUR 249.6
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.

Cycloguanil (hydrochloride)
C5763-10	ApexBio	10 mg	EUR 130.8
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Cycloguanil (hydrochloride)
C5763-25	ApexBio	25 mg	EUR 195.6
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Cycloguanil (hydrochloride)
C5763-50	ApexBio	50 mg	EUR 247.2
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Bufuralol (hydrochloride)
C5043-1	ApexBio	1 mg	EUR 166.8
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

Bufuralol (hydrochloride)
C5043-10	ApexBio	10 mg	EUR 753.6
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

Bufuralol (hydrochloride)
C5043-5	ApexBio	5 mg	EUR 548.4
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

AN3365 (hydrochloride)
C5068-10	ApexBio	10 mg	EUR 393.6
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

AN3365 (hydrochloride)
C5068-25	ApexBio	25 mg	EUR 790.8
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

AN3365 (hydrochloride)
C5068-5	ApexBio	5 mg	EUR 247.2
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

Calindol (hydrochloride)
C5329-10	ApexBio	10 mg	EUR 528
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Calindol (hydrochloride)
C5329-25	ApexBio	25 mg	EUR 1082.4
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Calindol (hydrochloride)
C5329-5	ApexBio	5 mg	EUR 324
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Kasugamycin (hydrochloride)
C5503-10000	ApexBio	10 g	EUR 420
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside.

Kasugamycin (hydrochloride)
C5503-5000	ApexBio	5 g	EUR 301.2
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside.

Ciprofloxacin (hydrochloride)
C5539-10000	ApexBio	10 g	EUR 139.2
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Ciprofloxacin (hydrochloride)
C5539-25000	ApexBio	25 g	EUR 184.8
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Ciprofloxacin (hydrochloride)
C5539-50000	ApexBio	50 g	EUR 268.8
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Fendiline (hydrochloride)
C5675-5000	ApexBio	5 g	EUR 146.4
Description: Fendiline is an ?2-adrenergic receptor antagonist and L-type calcium channel blocker [1,2].The ?2 adrenergic receptor is a G protein-coupled receptor (GPCR). Until now, three different ?2-receptor subtypes have been identified: ?2A, ?2B, and ?2C.

Daunorubicin Hydrochloride
ADC-P-011	Creative Biolabs	unit	Ask for price

Doxorubicin hydrochloride
ADC-P-014	Creative Biolabs	unit	Ask for price

MMAD hydrochloride
ADC-P-019	Creative Biolabs	unit	Ask for price

MMAF Hydrochloride
ADC-P-021	Creative Biolabs	unit	Ask for price

Taltobulin hydrochloride
ADC-P-027	Creative Biolabs	unit	Ask for price

Moxifloxacin hydrochloride
E1KS1465	EnoGene	50mg	EUR 296.4

(±)-Salsolinol (hydrochloride)
C4364-500	ApexBio	500 mg	EUR 369.6
Description: (±)-Salsolinol targets depolarize dopamineric neurons. Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions.

Midodrine (hydrochloride)
C4493-100	ApexBio	100 mg	EUR 135.6
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Midodrine (hydrochloride)
C4493-250	ApexBio	250 mg	EUR 240
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Celiprolol (hydrochloride)
C4521-10	ApexBio	10 mg	EUR 304.8
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)
C4521-25	ApexBio	25 mg	EUR 600
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)
C4521-5	ApexBio	5 mg	EUR 219.6
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Aceclidine (hydrochloride)
C4635-1000	ApexBio	1 g	EUR 393.6