Cell culture-derived influenza vaccines in the severe 2017-2018 epidemic season: a step towards improved influenza vaccine effectiveness.

The 2017-2018 seasonal influenza epidemics are severe in the US and Australia where A (H3N2) virus subtype dominated. Although circulating A (H3N2) virus antigen is not different from that recommended by the WHO for vaccine production, the overall interim estimate of vaccine effectiveness was under the historical average (33%) for A (H3N2) virus. The majority (USA) or all (Australia) dose of vaccine contains several amino acid changes in the hemagglutinin protein, which is produced from the necessary adaptation of the virus to embryonated chicken eggs used to manufacture the vaccine most. Previous reports have suggested the potential negative impact of the substitution of egg-driven performance of the vaccine. With the support of Barda, two vaccines licensed in the US is produced in cell culture: a recombinant influenza vaccine (RIV, Flublok ™) produced in insect cells and inactivated vaccines adult mammalian cells (ccIIV, Flucelvax ™). CcIIV quadrivalent (ccIIV4) vaccine for the 2017-2018 influenza season was produced using seed virus A (H3N2) distributed exclusively in cell culture and therefore less adaptative changes eggs. ccIIV dose fairly distributed (but not RIV dose) to allow the initial estimates of higher efficacy relative to traditional egg-based vaccine, the study details pending. The increased availability of certain product comparison vaccine effectiveness estimates for cell-based vaccine and egg-based can provide important clues to inform vaccine product improvements moving forward.

Diclofenac Diethylamine
B1928-50	ApexBio	50 mg	EUR 128
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac Diethylamine
B1928-S	ApexBio	Evaluation Sample	EUR 81
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Diclofenac diethylamine
20-abx185392	Abbexa	EUR 425.00 EUR 244.00	25 g 5 g
Shipped within 1-2 weeks.

Diclofenac (diethylamine)
HY-15036A	MedChemExpress	10mM/1mL	EUR 113

TAME Hydrochloride
2050-100	Biovision		EUR 126

TAME Hydrochloride
2050-1000	Biovision		EUR 479

TAME Hydrochloride
2050-500	Biovision		EUR 338

Verapamil hydrochloride
2861-1G	Biovision		EUR 131

Verapamil hydrochloride
2861-5G	Biovision		EUR 327

Ticlopidine hydrochloride
2919-25	Biovision		EUR 403

Ticlopidine hydrochloride
2919-5	Biovision		EUR 153

EHNA hydrochloride
2265-25	Biovision		EUR 283

EHNA hydrochloride
2265-5	Biovision		EUR 115

AdipoRon hydrochloride
2572-25	Biovision		EUR 588

AdipoRon hydrochloride
2572-5	Biovision		EUR 185

Pargyline hydrochloride
2618-1000	Biovision		EUR 175

Pargyline hydrochloride
2618-500	Biovision		EUR 120

Clorgyline hydrochloride
2622-10	Biovision		EUR 120

Clorgyline hydrochloride
2622-50	Biovision		EUR 327

Clindamycin hydrochloride
2627-10	Biovision		EUR 131

Clindamycin hydrochloride
2627-50	Biovision		EUR 370

Loperamide hydrochloride
2683-1000	Biovision		EUR 185

Loperamide hydrochloride
2683-500	Biovision		EUR 131

Clonidine hydrochloride
2684-100	Biovision		EUR 131

Clonidine hydrochloride
2684-500	Biovision		EUR 359

Leelamine hydrochloride
2717-25	Biovision		EUR 457

Leelamine hydrochloride
2717-5	Biovision		EUR 153

SBE13 hydrochloride
2847-10	Biovision		EUR 185

SBE13 hydrochloride
2847-50	Biovision		EUR 588

Amodiaquine hydrochloride
A085-5G	TOKU-E	5 g	EUR 55

Metformin, Hydrochloride
1691-5G	Biovision		EUR 158

Irinotecan Hydrochloride
1752-250	Biovision		EUR 387

Irinotecan Hydrochloride
1752-50	Biovision		EUR 147

Epirubicin Hydrochloride
1753-25	Biovision		EUR 457

Epirubicin Hydrochloride
1753-5	Biovision		EUR 158

Gemcitabine Hydrochloride
1759-100	Biovision		EUR 370

Gemcitabine Hydrochloride
1759-25	Biovision		EUR 156

Amiodarone Hydrochloride
1828-100	Biovision		EUR 126

Amiodarone Hydrochloride
1828-500	Biovision		EUR 338

Phenformin hydrochloride
1889-100	Biovision		EUR 115

Phenformin hydrochloride
1889-1000	Biovision		EUR 359

Tomatidine hydrochloride
1893-25	Biovision		EUR 137

Vancomycin Hydrochloride
B1507-1G	Biovision		EUR 153

Vancomycin Hydrochloride
B1507-250	Biovision		EUR 120

Vancomycin Hydrochloride
B1507-5G	Biovision		EUR 262

Lincomycin Hydrochloride
B1524-1G	Biovision		EUR 142

Lincomycin Hydrochloride
B1524-5G	Biovision		EUR 403

Minocycline Hydrochloride
B1525-250	Biovision		EUR 414

Minocycline Hydrochloride
B1525-50	Biovision		EUR 142

Oxytetracycline Hydrochloride
B1527-25G	Biovision		EUR 229

Oxytetracycline Hydrochloride
B1527-5G	Biovision		EUR 109

Tetracycline Hydrochloride
B1535-10G	Biovision		EUR 109

Tetracycline Hydrochloride
B1535-50G	Biovision		EUR 196

Hydroxyfasudil Hydrochloride
B1559-25	Biovision		EUR 631

Hydroxyfasudil Hydrochloride
B1559-5	Biovision		EUR 196

Thioridazine Hydrochloride
B1581-1G	Biovision		EUR 120

Thioridazine Hydrochloride
B1581-5G	Biovision		EUR 327

Ivabradine Hydrochloride
B1595-10	Biovision		EUR 142

Bendamustine Hydrochloride
B1596-25	Biovision		EUR 457

Bendamustine Hydrochloride
B1596-5	Biovision		EUR 153

Afuresertib hydrochloride
B1848-5	Biovision		EUR 175

Chlorpromazine hydrochloride
B1992-100	Biovision		EUR 120

Chlorpromazine hydrochloride
B1992-500	Biovision		EUR 294

Triflupromazine hydrochloride
B1993-100	Biovision		EUR 120

ZLN024 hydrochloride
B2034-25	Biovision		EUR 588

ZLN024 hydrochloride
B2034-5	Biovision		EUR 185

Topotecan hydrochloride
B2050-10	Biovision		EUR 131

Givinostat hydrochloride
B2081-25	Biovision		EUR 756

Givinostat hydrochloride
B2081-5	Biovision		EUR 229

Moexipril hydrochloride
B2134-25	Biovision		EUR 294

Imidapril hydrochloride
B2135-25	Biovision		EUR 414

Imidapril hydrochloride
B2135-5	Biovision		EUR 142

Benazepril hydrochloride
B2138-250	Biovision		EUR 294

Benazepril hydrochloride
B2138-50	Biovision		EUR 131

Dorzolamide hydrochloride
B2185-10	Biovision		EUR 120

Dorzolamide hydrochloride
B2185-50	Biovision		EUR 327

Eltoprazine hydrochloride
B2301-25	Biovision		EUR 457

Eltoprazine hydrochloride
B2301-5	Biovision		EUR 153

Papaverine hydrochloride
B2315-250	Biovision		EUR 262

Papaverine hydrochloride
B2315-50	Biovision		EUR 120

Sarecycline hydrochloride
B2383-25	Biovision		EUR 588

Sarecycline hydrochloride
B2383-5	Biovision		EUR 185

Sertraline (hydrochloride)
B2393-10	Biovision		EUR 131

Sertraline (hydrochloride)
B2393-50	Biovision		EUR 327

Migalastat hydrochloride
B2404-25	Biovision		EUR 756

Migalastat hydrochloride
B2404-5	Biovision		EUR 229

Butenafine hydrochloride
B2421-250	Biovision		EUR 327

Butenafine hydrochloride
B2421-50	Biovision		EUR 120

Naftifine hydrochloride
B2422-10	Biovision		EUR 131

Naftifine hydrochloride
B2422-50	Biovision		EUR 349

Rilpivirine hydrochloride
B2427-25	Biovision		EUR 414

Rilpivirine hydrochloride
B2427-5	Biovision		EUR 142

Tirabrutinib hydrochloride
B2556-25	Biovision		EUR 457

Tirabrutinib hydrochloride
B2556-5	Biovision		EUR 153

Robenidine hydrochloride
B2560-1G	Biovision		EUR 131

Robenidine hydrochloride
B2560-5G	Biovision		EUR 262

Sardomozide Hydrochloride
B2566-25	Biovision		EUR 631

Sardomozide Hydrochloride
B2566-5	Biovision		EUR 196