The 2017-2018 seasonal influenza epidemics are severe in the US and Australia where A (H3N2) virus subtype dominated. Although circulating A (H3N2) virus antigen is not different from that recommended by the WHO for vaccine production, the overall interim estimate of vaccine effectiveness was under the historical average (33%) for A (H3N2) virus. The majority (USA) or all (Australia) dose of vaccine contains several amino acid changes in the hemagglutinin protein, which is produced from the necessary adaptation of the virus to embryonated chicken eggs used to manufacture the vaccine most. Previous reports have suggested the potential negative impact of the substitution of egg-driven performance of the vaccine. With the support of Barda, two vaccines licensed in the US is produced in cell culture: a recombinant influenza vaccine (RIV, Flublok ™) produced in insect cells and inactivated vaccines adult mammalian cells (ccIIV, Flucelvax ™). CcIIV quadrivalent (ccIIV4) vaccine for the 2017-2018 influenza season was produced using seed virus A (H3N2) distributed exclusively in cell culture and therefore less adaptative changes eggs. ccIIV dose fairly distributed (but not RIV dose) to allow the initial estimates of higher efficacy relative to traditional egg-based vaccine, the study details pending. The increased availability of certain product comparison vaccine effectiveness estimates for cell-based vaccine and egg-based can provide important clues to inform vaccine product improvements moving forward.
Diclofenac diethylamine |
20-abx185392 |
Abbexa |
|
|
|
Diclofenac Diethylamine |
B1928-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
Diclofenac Diethylamine |
B1928-50 |
ApexBio |
50 mg |
EUR 153.6 |
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
Diclofenac Diethylamine |
B1928-S |
ApexBio |
Evaluation Sample |
EUR 97.2 |
Description: Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
Diethylamino hydroxybenzoyl hexyl benzoate |
HY-109656 |
MedChemExpress |
100mg |
EUR 142.8 |
4-(Diethylamino)butylamine |
20-abx180467 |
Abbexa |
-
EUR 326.40
-
EUR 1395.60
-
EUR 594.00
|
|
|
3-Diethylamino-1-Propanol |
20-abx181113 |
Abbexa |
-
EUR 577.20
-
EUR 343.20
-
EUR 243.60
|
|
|
2‐AMINO ACETAMIDE HYDROCHLORIDE (GLYCINAMIDE HYDROCHLORIDE) |
101003 |
Survival Technologies |
each |
Ask for price |
5-Diethylamino-2-Pentanone |
abx188533-500g |
Abbexa |
500 g |
EUR 2064 |
|
4-(Diethylamino)salicylaldehyde |
20-abx184588 |
Abbexa |
|
|
|
DiEthylAmino Magnetic Particles |
DEM-30-10 |
Spherotech |
10 mL |
EUR 261.6 |
Description: DiEthylAmino Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team. |
DOI hydrochloride |
B5321-10 |
ApexBio |
10 mg |
EUR 205.2 |
DOI hydrochloride |
B5321-5 |
ApexBio |
5 mg |
EUR 141.6 |
DOI hydrochloride |
B5321-50 |
ApexBio |
50 mg |
EUR 714 |
DOB hydrochloride |
B5344-1 |
ApexBio |
1 mg |
EUR 141.6 |
Q94 hydrochloride |
B5705-10 |
ApexBio |
10 mg |
EUR 350.4 |
Q94 hydrochloride |
B5705-50 |
ApexBio |
50 mg |
EUR 1264.8 |
GMQ hydrochloride |
B5793-10 |
ApexBio |
10 mg |
EUR 212.4 |
GMQ hydrochloride |
B5793-50 |
ApexBio |
50 mg |
EUR 711.6 |
AMT hydrochloride |
B6480-10 |
ApexBio |
10 mg |
EUR 205.2 |
AMT hydrochloride |
B6480-100 |
ApexBio |
100 mg |
EUR 1036.8 |
AMT hydrochloride |
B6480-5 |
ApexBio |
5 mg |
EUR 141.6 |
AMT hydrochloride |
B6480-50 |
ApexBio |
50 mg |
EUR 673.2 |
AMTB hydrochloride |
B2978-25 |
Biovision |
25 mg |
EUR 812.4 |
AMTB hydrochloride |
B2978-5 |
Biovision |
5 mg |
EUR 247.2 |
MPEP hydrochloride |
B1151-10 |
Biovision |
each |
EUR 222 |
MPEP hydrochloride |
B1151-50 |
Biovision |
each |
EUR 705.6 |
S1RA hydrochloride |
B1180-10 |
ApexBio |
10 mg |
EUR 1144.8 |
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models. |
S1RA hydrochloride |
B1180-100 |
ApexBio |
100 mg |
EUR 4620 |
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models. |
S1RA hydrochloride |
B1180-5 |
ApexBio |
5 mg |
EUR 819.6 |
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models. |
S1RA hydrochloride |
B1180-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 895.2 |
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models. |
S1RA hydrochloride |
B1180-50 |
ApexBio |
50 mg |
EUR 3316.8 |
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models. |
THZ1 Hydrochloride |
B4736-10 |
ApexBio |
10 mg |
EUR 268.8 |
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity. |
THZ1 Hydrochloride |
B4736-25 |
ApexBio |
25 mg |
EUR 477.6 |
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity. |
THZ1 Hydrochloride |
B4736-5 |
ApexBio |
5 mg |
EUR 170.4 |
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity. |
THZ1 Hydrochloride |
B4736-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 205.2 |
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity. |
EHNA hydrochloride |
2265-25 |
Biovision |
each |
EUR 339.6 |
EHNA hydrochloride |
2265-5 |
Biovision |
each |
EUR 138 |
TAME Hydrochloride |
2050-100 |
Biovision |
each |
EUR 151.2 |
TAME Hydrochloride |
2050-1000 |
Biovision |
each |
EUR 574.8 |
TAME Hydrochloride |
2050-500 |
Biovision |
each |
EUR 405.6 |
DMCM hydrochloride |
B7268-10 |
ApexBio |
10 mg |
EUR 385.2 |
DMCM hydrochloride |
B7268-100 |
ApexBio |
100 mg |
EUR 2210.4 |
DMCM hydrochloride |
B7268-25 |
ApexBio |
25 mg |
EUR 776.4 |
DMCM hydrochloride |
B7268-5 |
ApexBio |
5 mg |
EUR 277.2 |
DMCM hydrochloride |
B7268-5.1 |
ApexBio |
10 mM (in 1mL H2O) |
EUR 297.6 |
DMCM hydrochloride |
B7268-50 |
ApexBio |
50 mg |
EUR 1363.2 |
TRIS hydrochloride |
B7299-500000 |
ApexBio |
500 g |
EUR 309.6 |
AMTB hydrochloride |
B7559-10 |
ApexBio |
10 mg |
EUR 459.6 |
AMTB hydrochloride |
B7559-50 |
ApexBio |
50 mg |
EUR 1746 |
MPEP Hydrochloride |
A3633-10 |
ApexBio |
10 mg |
EUR 142.8 |
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system. |
MPEP Hydrochloride |
A3633-50 |
ApexBio |
50 mg |
EUR 379.2 |
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system. |
MPTP hydrochloride |
A3634-10 |
ApexBio |
10 mg |
EUR 162 |
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1]. |
MPTP hydrochloride |
A3634-50 |
ApexBio |
50 mg |
EUR 344.4 |
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1]. |
MTEP hydrochloride |
A3636-10 |
ApexBio |
10 mg |
EUR 205.2 |
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8). |
MTEP hydrochloride |
A3636-5 |
ApexBio |
5 mg |
EUR 153.6 |
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8). |
MTEP hydrochloride |
A3636-50 |
ApexBio |
50 mg |
EUR 686.4 |
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8). |
PJ34 hydrochloride |
A4159-10 |
ApexBio |
10 mg |
EUR 142.8 |
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
PJ34 hydrochloride |
A4159-5 |
ApexBio |
5 mg |
EUR 129.6 |
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
PJ34 hydrochloride |
A4159-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 150 |
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
PJ34 hydrochloride |
A4159-50 |
ApexBio |
50 mg |
EUR 296.4 |
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
PJ34 hydrochloride |
A4159-S |
ApexBio |
Evaluation Sample |
EUR 97.2 |
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
TCEP hydrochloride |
B6055-10000 |
ApexBio |
10 g |
EUR 338.4 |
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid. |
TCEP hydrochloride |
B6055-2000 |
ApexBio |
2 g |
EUR 150 |
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid. |
TCEP hydrochloride |
B6055-50000 |
ApexBio |
50 g |
EUR 1243.2 |
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid. |
HEAT hydrochloride |
B6339-10 |
ApexBio |
10 mg |
EUR 321.6 |
HEAT hydrochloride |
B6339-50 |
ApexBio |
50 mg |
EUR 1167.6 |
THIP hydrochloride |
B6460-100 |
ApexBio |
100 mg |
EUR 358.8 |
THIP hydrochloride |
B6460-25 |
ApexBio |
25 mg |
EUR 174 |
THIP hydrochloride |
B6460-50 |
ApexBio |
50 mg |
EUR 243.6 |
EHNA hydrochloride |
B6662-10 |
ApexBio |
10 mg |
EUR 145.2 |
EHNA hydrochloride |
B6662-25 |
ApexBio |
25 mg |
EUR 262.8 |
N20C hydrochloride |
B6980-10 |
ApexBio |
10 mg |
EUR 340.8 |
N20C hydrochloride |
B6980-50 |
ApexBio |
50 mg |
EUR 1245.6 |
TMPH hydrochloride |
B7053-10 |
ApexBio |
10 mg |
EUR 321.6 |
TMPH hydrochloride |
B7053-50 |
ApexBio |
50 mg |
EUR 1167.6 |
DAPI (hydrochloride) |
C3362-10 |
ApexBio |
10 mg |
EUR 146.4 |
DAPI (hydrochloride) |
C3362-25 |
ApexBio |
25 mg |
EUR 240 |
DAPI (hydrochloride) |
C3362-5 |
ApexBio |
5 mg |
EUR 111.6 |
AD57 (hydrochloride) |
C3080-1 |
ApexBio |
1 mg |
EUR 141.6 |
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. |
AD57 (hydrochloride) |
C3080-10 |
ApexBio |
10 mg |
EUR 714 |
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. |
AD57 (hydrochloride) |
C3080-5 |
ApexBio |
5 mg |
EUR 428.4 |
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. |
THZ1 hydrochloride |
9544-25 |
Biovision |
each |
EUR 1227.6 |
THZ1 hydrochloride |
9544-5 |
Biovision |
each |
EUR 366 |
EDAC, hydrochloride |
EB0433 |
Bio Basic |
25g |
EUR 123.68 |
|
TCEP hydrochloride |
TB0974 |
Bio Basic |
1g |
EUR 101.76 |
|
Tris hydrochloride |
TB0103 |
Bio Basic |
250g |
EUR 84.01 |
|
Diethylaminosulfur trifluoride |
20-abx180722 |
Abbexa |
-
EUR 678.00
-
EUR 360.00
-
EUR 2214.00
-
EUR 260.40
|
|
|
CPTH2 (hydrochloride) |
B2815-1 |
Biovision |
each |
EUR 144 |
CPTH2 (hydrochloride) |
B2815-5 |
Biovision |
each |
EUR 352.8 |
XL413 hydrochloride |
B1015-10 |
ApexBio |
10 mg |
EUR 289.2 |
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1 |
XL413 hydrochloride |
B1015-100 |
ApexBio |
100 mg |
EUR 1005.6 |
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1 |
XL413 hydrochloride |
B1015-5 |
ApexBio |
5 mg |
EUR 205.2 |
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1 |
XL413 hydrochloride |
B1015-50 |
ApexBio |
50 mg |
EUR 714 |
Description: XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1 |
SMANT hydrochloride |
B5674-10 |
ApexBio |
10 mg |
EUR 350.4 |
SMANT hydrochloride |
B5674-50 |
ApexBio |
50 mg |
EUR 1284 |
SBE13 hydrochloride |
2847-10 |
Biovision |
each |
EUR 222 |
SBE13 hydrochloride |
2847-50 |
Biovision |
each |
EUR 705.6 |
MS049 (hydrochloride) |
C3776-10 |
ApexBio |
10 mg |
EUR 240 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-100 |
ApexBio |
100 mg |
EUR 1417.2 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-25 |
ApexBio |
25 mg |
EUR 458.4 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-5 |
ApexBio |
5 mg |
EUR 166.8 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 180 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-50 |
ApexBio |
50 mg |
EUR 783.6 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
VU590 (hydrochloride) |
C4778-10 |
ApexBio |
10 mg |
EUR 234 |
VU590 (hydrochloride) |
C4778-25 |
ApexBio |
25 mg |
EUR 466.8 |
VU590 (hydrochloride) |
C4778-5 |
ApexBio |
5 mg |
EUR 166.8 |
MMPIP hydrochloride |
B7234-1 |
ApexBio |
1 mg |
EUR 151.2 |
MMPIP hydrochloride |
B7234-10 |
ApexBio |
10 mg |
EUR 308.4 |